Selected research by the 2020 Nobel Laureates
Research by Laureates in Medicine or Physiology
Harvey J. Alter
Journal of Hepatology
The Lancet
- CLINICAL AND SEROLOGICAL ANALYSIS OF TRANSFUSION-ASSOCIATED HEPATITIS (1975)
- TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS (1978)
Vaccine
- Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults (2010)
Virology
Virus Research
- Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies – Open Access (2018)
Michael A. Houghton
Antiviral Research
Cell Chemical Biology
- Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1 – Open Access (2020)
Immunity
- Analysis of a successful immune response against hepatitis C virus – Open Access (1999)
- The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes – Open Access (2001)
Journal of Hepatology
- The long and winding road leading to the identification of the hepatitis C virus – Open Access (2009)
Vaccine
- Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults (2010)
Virology
Virus Research
- Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies – Open Access (2018)
Charles M. Rice
Antiviral Research
- Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals – Open Access (2013)
Cell
- Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids – Open Access (2018)
- Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown – Open Access (2018)
- Intrinsic Immunity Shapes Viral Resistance of Stem Cells – Open Access (2018)
- Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico – Open Access (2017)
- Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity – Open Access (2015)
- Hepatitis C virus RNA functionally sequesters miR-122 – Open Access (2015)
- A serpin shapes the extracellular environment to prevent influenza a virus maturation – Open Access (2015)
- Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide – Open Access (1996)
Cell Host & Microbe
- Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread – Open Access (2017)
- Identification of Interferon-Stimulated Genes with Antiretroviral Activity – Open Access (2016)
- A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration – Open Access (2016)
- Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness – Open Access (2014)
- Inhibition of HIV-1 particle assembly by 2′,3′-cyclic- nucleotide 3′-Phosphodiesterase – Open Access (2012)
- Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook – Open Access (2009)
Cell Reports
- A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates – Open Access (2018)
- NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus – Open Access (2018)
- Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b – Open Access (2017)
- Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry – Open Access (2015)
Cellular and Molecular Gastroenterology and Hepatology
- Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice – Open Access (2017)
Immunity
- The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity – Open Access (2017)
- The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus – Open Access (2015)
Journal of Hepatology
- Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122 – Open Access (2016)
- Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice – Open Access (2011)
Molecular Cell
- Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer – Open Access (2017)
- ATP-Dependent effector-like functions of RIG-I-like receptors – Open Access (2015)
- RNAi targeting an animal virus: News from the front – Open Access (2002)
Virology
- Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies – Open Access (2016)
- Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines – Open Access (2013)
- Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein – Open Access (2013)
Virus Research
- Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies – Open Access (2018)
Research by Laureates in Chemistry
Emmanuelle Charpentier
Cell
- The Biology of CRISPR-Cas: Backward and Forward – Open Access (2018)
Cell Reports
- Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria – Open Access (2013)
Molecular Cell
- Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence – Open Access (2019)
- Adaptation in CRISPR-Cas Systems – Open Access (2016)
Trends in Microbiology
Virology
- Memory of viral infections by CRISPR-Cas adaptive immune systems: Acquisition of new information – Open Access (2012)
Jennifer A. Doudna
Cell
- CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification – Open Access (2019)
- The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders – Open Access (2018)
- A Broad-Spectrum Inhibitor of CRISPR-Cas9 – Open Access (2017)
- Programmable RNA Tracking in Live Cells with CRISPR/Cas9 – Open Access (2016)
- Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering – Open Access (2016)
- Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System – Open Access (2015)
- Structure-guided reprogramming of human cgas dinucleotide linkage specificity – Open Access (2014)
- CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes – Open Access (2013)
- Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression – Open Access (2013)
Cell Reports
- RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a – Open Access (2018)
- Widespread Translational Remodeling during Human Neuronal Differentiation – Open Access (2017)
- A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells – Open Access (2016)
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity – Open Access (2013)
Molecular Cell
- A scoutRNA Is Required for Some Type V CRISPR-Cas Systems (2020)
- A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System – Open Access (2019)
- DNA Targeting by a Minimal CRISPR RNA-Guided Cascade – Open Access (2016)
- CRISPR Immunological Memory Requires a Host Factor for Specificity – Open Access (2016)
- Expanding the Biologist's Toolkit with CRISPR-Cas9 – Open Access (2015)
Structure
- Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense – Open Access (2009)
Источник: https://www.elsevier.com/connect/honoring-the-2020-nobel-laureates
