The 2015 Nobel Prize in Chemistry has been jointly awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for “mechanistic studies of DNA repair”. Their studies provided much introspection into the fundamental mechanism of cellular repair and this knowledge is highly translational and applicable, for instance, in the development of novel cancer therapy.
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Tomas Lindahl
DNA base excision repair of uracil residues in reconstituted nucleosome core particles
The EMBO Journal
Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase
The EMBO Journal
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
The EMBO Journal
The Action Pattern of Mammalian Deoxyribonuclease IV, Eur. J. Biochem.
European Journal of Biochemistry
Excision of Pyrimidine Dimers from Ultraviolet-Irradiated DNA by Exonucleases from Mammalian Cells
European Journal of Biochemistry
| Encyclopedia Of Molecular Medicine Online ISBN: 9780471203070 | Ciba Foundation Symposium 211 - Telomeres and Telomerase Online ISBN: 9780470515433 |
Paul Modrich
MutS mediates heteroduplex loop formation by a translocation mechanism
The EMBO Journal
Aziz Sancar
Nucleotide Excision Repair
Photochemistry and Photobiology
(A)BC excinuclease: the Escherichia coli nucleotide excision repair enzyme
Molecular Microbiology
Melanoma and DNA damage from a distance (farstander effect)
Pigment Cell & Melanoma Research
Photochemistry and Photobiology of Cryptochrome Blue-light Photopigments: The Search for a Photocycle
Photochemistry and Photobiology
Photoreactivation of Killing INE. coliK?12 phr- Cells is not Caused by Pyrimidine Dimer Reversal
Photochemistry and Photobiology
| Wiley Encyclopedia of Chemical Biology: DNA Damage - Repair Online ISBN: 9780470048672 | Handbook of Photosensory Receptors: Chapter 12. Animal Cryptochromes Online ISBN: 9783527605101 |
| Encyclopedia Of Molecular Biology: O6-Methylguanine-DNA Methyltransferase (MGMT) Online ISBN: 9780471209188 | Encyclopedia Of Molecular Biology: AP Endonucleases Online ISBN: 9780471209188 |
| Encyclopedia Of Molecular Biology: Base Excision Repair Online ISBN: 9780471209188 | Encyclopedia Of Molecular Medicine: Recombinational Repair Online ISBN: 9780471209188 |
| Encyclopedia Of Molecular Medicine: DNA Repair Online ISBN: 9780471209188 |
Did you know? Biochemistry is the most common research field for Chemistry Nobel Laureates.
Источник: Wiley, wileyasiablog
