The January special issue of Cell Research on Stem Cell Biology brings together the latest reviews and articles in the field. Together with the accompanying web focus, Cell Research delves into our current understanding and investigates recent advances in various aspects of stem cell biology, cell reprogramming, and their relevance to diseases.
Understanding cancer stem cell heterogeneity and plasticity
Dean G Tang
Modeling sarcomagenesis using multipotent mesenchymal stem cells
Rene Rodriguez, Ruth Rubio and Pablo Menendez
Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice
Yixuan Wang, Chen-Guang Zheng, Yonghua Jiang, Jiqin Zhang, Jiayu Chen, Chao Yao, Qingguo Zhao, Sheng Liu, Ke Chen, Juan Du, Ze Yang and Shaorong Gao
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells Xinjian Liu, Fang Li, Elizabeth A Stubblefield, Barbara Blanchard, Toni L Richards, Gaynor A Larson, Yujun He, Qian Huang, Aik-Choon Tan, Dabing Zhang, Timothy A Benke, John R Sladek, Nancy R Zahniser and Chuan-Yuan Li
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
Chao Sheng, Qinyuan Zheng, Jianyu Wu, Zhen Xu, Libin Wang, Wei Li, Haijiang Zhang, Xiao-Yang Zhao, Lei Liu, Ziwei Wang, Changlong Guo, Hua-Jun Wu, Zhonghua Liu, Liu Wang, Shigang He, Xiu-Jie Wang, Zhiguo Chen and Qi Zhou
TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy
Chengyan Wang, Xuming Tang, Xiaomeng Sun, Zhenchuan Miao, Yaxin Lv, Yanlei Yang, Huidan Zhang, Pengbo Zhang, Yang Liu, Liying Du, Yang Gao, Ming Yin, Mingxiao Ding and Hongkui Deng
Defining the nature of human pluripotent stem cell progeny
Michaela Patterson, David N. Chan, Iris Ha, Dana Case, Yongyan Cui, Ben Van Hande, Hanna KA Mikkola and William E Lowry
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
Athanasia D Panopoulos, Oscar Yanes, Sergio Ruiz, Yasuyuki S Kida, Dinh Diep, Ralf Tautenhahn, Aída Herrerías, Erika M Batchelder, Nongluk Plongthongkum, Margaret Lutz, W Travis Berggren, Kun Zhang, Ronald M Evans, Gary Siuzdak and Juan Carlos Izpisua Belmonte
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
Huansheng Xu, B Alexander Yi, Hao Wu, Christoph Bock, Hongcang Gu, Kathy O Lui, Joo-Hye C Park, Ying Shao, Alyssa K Riley, Ibrahim J Domian, Erding Hu, Robert Willette, John Lepore, Alexander Meissner, Zhong Wang and Kenneth R Chien