Cell Research is proud to present a collection of featured articles from 2012 from across the fields of basic molecular and cell biology research. These articles have been chosen by the Editor to illustrate some of the latest advances in topics such as stem cells, autophagy, cancer biology, miRNAs, trafficking, and immunity.
Polarized sorting and trafficking in epithelial cells
Xinwang Cao, Michal A Surma and Kai Simons
Regulation of small RNA stability: methylation and beyond
Lijuan Ji and Xuemei Chen
Understanding cancer stem cell heterogeneity and plasticity
Dean G Tang
Autophagy: for better or for worse
Ellen Wirawan, Tom Vanden Berghe, Saskia Lippens, Patrizia Agostinis and Peter Vandenabeele
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms
Zhenlin Yang, Huanhuan Liang, Qian Zhou, Ying Li, Haiwei Chen, Wen Ye, Danying Chen, Joy Fleming, Hongbing Shu and Yingfang Liu
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
Michael Steckel, Miriam Molina-Arcas, Britta Weigelt, Michaela Marani, Patricia H Warne, Hanna Kuznetsov, Gavin Kelly, Becky Saunders, Michael Howell, Julian Downward and David C Hancock
Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization
Wen-Liang Lei, Shi-Ge Xing, Cai-Yun Deng, Xiang-Chun Ju, Xing-Yu Jiang and Zhen-Ge Luo
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Weijiao Huang, Wooyoung Choi, Wanqiu Hu, Na Mi, Qiang Guo, Meisheng Ma, Mei Liu, Yuan Tian, Peilong Lu, Feng-Liang Wang, Haiteng Deng, Lei Liu, Ning Gao, Li Yu and Yigong Shi
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
Huansheng Xu, B Alexander Yi, Hao Wu, Christoph Bock, Hongcang Gu, Kathy O Lui, Joo-Hye C Park, Ying Shao, Alyssa K Riley, Ibrahim J Domian, Erding Hu, Robert Willette, John Lepore, Alexander Meissner, Zhong Wang and Kenneth R Chien
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
Lin Zhang, Dongxia Hou, Xi Chen, Donghai Li, Lingyun Zhu, Yujing Zhang, Jing Li, Zhen Bian, Xiangying Liang, Xing Cai, Yuan Yin, Cheng Wang, Tianfu Zhang, Dihan Zhu, Dianmu Zhang, Jie Xu, Qun Chen, Yi Ba, Jing Liu, Qiang Wang, Jianqun Chen, Jin Wang, Meng Wang, Qipeng Zhang, Junfeng Zhang, Ke Zen and Chen-Yu Zhang
