На сайте Elsevier выложены в свободном доступе статьи Нобелевских лауреатов по медицине 2019 г., опубликованные в журналах Издательства
Research by Nobel Laureates in Physiology or Medicine
William G. Kaelin Jr.
Biochemical and Biophysical Research Communications
Cancer Cell
- TSC2 regulates VEGF through mTOR-dependent and -independent pathways – Open Access (2003)
- Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer – Open Access (2005)
- Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes – Open Access (2004)
- Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase – Open Access (2009)
- Kidney cancer: now available in a new flavor – Open Access (2008)
- SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling – Open Access (2009)
Cell
- Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine – Open Access (2016)
- EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection – Open Access (2016)
Cell Metabolism
- ROS: Really involved in Oxygen Sensing – Open Access (2005)
Molecular Cell
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway – Open Access (2008)
- The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix – Open Access (1998)
- Binding of pRB to the PHD protein RBP2 promotes cellular differentiation – Open Access (2005)
- pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2 – Open Access (2007)
- The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks– Open Access (2017)
The Molecular Basis of Cancer: Fourth Edition
- Molecular Abnormalities in Kidney Cancer (2014)
Sir Peter J. Ratcliffe
BBA - Gene Structure and Expression
Cancer Cell
- HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability – Open Access (2005)
- Fumarate hydratase deficiency and cancer: activation of hypoxia signaling? – Open Access (2007)
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling – Open Access (2011)
Cell
- C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation – Open Access (2001)
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization – Open Access (2009)
Chemistry and Biology
- A photoreactive small-molecule probe for 2-oxoglutarate oxygenases – Open Access (2011)
Molecular Aspects of Medicine
Molecular Cell
Trends in Molecular Medicine
Gregg L. Semenza
Biochimica et Biophysica Acta - Molecular Cell Research
- Effect of protein kinase and phosphatase inhibitors on expression of hypoxia inducible factor 1 (1995)
- In vivo expression of mRNAs encoding hypoxia-inducible factor 1(1996)
- The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway(2004)
- Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases (2005)
- Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning (2011)
- The hypoxic tumor microenvironment: A driving force for breast cancer progression – Open Access (2016)
- Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors (2018)
Cancer Cell
- HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity – Open Access (2007)
- HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo – Open Access (2007)
- Intratumoral hypoxia, radiation resistance, and HIF-1 – Open Access (2004)
Cell
- Hypoxia-inducible factors in physiology and medicine – Open Access (2012)
- HIF-1, O2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus – Open Access (2001)
- HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells – Open Access (2007)
- Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 – Open Access (2011)
- Perspectives on oxygen sensing – Open Access (1999)
Cell Metabolism
- HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia – Open Access (2006)
Cell Stem Cell
- Metabolic regulation of hematopoietic stem cells in the hypoxic niche – Open Access (2011)
Molecular Aspects of Medicine
Molecular Cell
- RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α – Open Access (2007)
- OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α– Open Access (2005)
- MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1 – Open Access (2011)
Trends in Biochemical Sciences
Trends in Cancer
Trends in Molecular Medicine